Sarcoidosis and inclusion body myositis.

نویسندگان

  • G Vattemi
  • P Tonin
  • M Marini
  • M L Guadagnin
  • B Dal Pra
  • A Simonati
  • M Filosto
  • G Tomelleri
چکیده

directed against RANKL, has been demonstrated to increase bone mass at both axial and peripheral skeletal sites, as well as in trabecular and cortical areas of bone [8]. It can probably prevent not only the generalized bone loss in RA, but also the joint destruction inhibiting the bone erosion [9]. On the other hand, zoledronic acid is a potent third-generation aminobisphosphonate that is thought to act by inhibiting the osteoclast lifespan. It has been suggested that, added to MTX, it reduces the number of bone erosions in RA [10]. It seems clear that the new challenge in the treatment of RA should be not only to arrest the structural damage, but also to repair the previous erosions. Anti-TNFtherapy, zoledronic acid and denosumab, alone or in combined therapy, are among the potential candidates to achieve that ambitious but, we think, realistic goal.

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عنوان ژورنال:
  • Rheumatology

دوره 47 9  شماره 

صفحات  -

تاریخ انتشار 2008